On-the-Fly Encryption with TrueCrypt
Technical Introduction from TrueCrypt.org
TrueCrypt is a software system for establishing and maintaining an on-the-fly-encrypted volume (data storage device). On-the-fly encryption means that data is automatically encrypted or decrypted right before it is loaded or saved, without any user intervention. No data stored on an encrypted volume can be read (decrypted) without using the correct password/keyfile(s) [...]